Single-cell resolution of morphological changes in hemogenic endothelium
نویسندگان
چکیده
منابع مشابه
Hemogenic endothelium during development and beyond.
During embryonic development, multilineage HSCs/progenitor cells are derived from specialized endothelial cells, termed hemogenic endothelium, within the yolk sac, placenta, and aorta. Whether hemogenic endothelial cells contribute to blood cell development at other sites of definitive hematopoiesis, such as in the fetal liver and fetal bone marrow, is not known. Also unknown is whether such ce...
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Endothelium in embryonic hematopoietic tissues generates hematopoietic stem/progenitor cells; however, it is unknown how its unique potential is specified. We show that transcription factor Scl/Tal1 is essential for both establishing the hematopoietic transcriptional program in hemogenic endothelium and preventing its misspecification to a cardiomyogenic fate. Scl(-/-) embryos activated a cardi...
متن کاملCell signaling directing the formation and function of hemogenic endothelium during murine embryogenesis.
During developmental hematopoiesis, multilineage hematopoietic progenitors are thought to derive from a subset of vascular endothelium. Herein, we define the phenotype of such hemogenic endothelial cells and demonstrate, on a clonal level, that they exhibit multilineage hematopoietic potential. Furthermore, we have begun to define the molecular signals that regulate their development. We found ...
متن کاملMorphological changes in rabbit corneal endothelium after surgical injury.
PURPOSE To understand the responses of the corneal endothelium to different types of surgical insults, we chronologically investigated morphologic changes in rabbit endothelial cells after injury. METHODS We performed a mechanical incision, epithelial ablation, or excimer laser irradiation on rabbit corneas and observed the changes in the endothelial cells for up to 2 weeks after surgery unde...
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ژورنال
عنوان ژورنال: Development
سال: 2015
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.121350